Prof. Hamid Mirzadeh

Designing and Fabrication of a Biocomposite for Skin Tissue Engineering   

H. MIRZADEH*^1,2 , H. MAHDAVI^I  H. MORAVEJ FARSHI³

, M. MAHMODI RAD³, P. TOSI³

1-Polymeric Biomaterials Department, Iran Polymer and Petrochemical Institute,

Tehran, Iran

2-Polymer Engineering Department Amirkabir University of Technology

3-Skin Research Center of Shahid Beheshty Medical University (SBMU), Tehran, Iran

Email:mirzadeh@aut.ac.ir

The aim of this study was to develop a quartet composite film namely IPPISkin comprising  chitosan  (Cs),  glucose-amino-glycans  (GAGs),  collagen  (Col)/ gelatin   and polyvinylalcohol  (PVA)  as  dermal  substitute  for  treatment  of  dermal  burns  or injuries. 

In the previous work, the physical, chemical and mechanical properties of  the membrane  were  characterized  using  different  techniques  such  as  scanning electron  microscopy  (SEM),  Fourier  transform  infrared  (FTIR),  differential scanning calorimetry  (DSC) and dynamic mechanical  thermal analysis  (DMTA). Also  the  cytotoxicity  and  in  vitro  culture  studies  were  performed  using  L929 fibroblast cell line. The blend membrane was evaluated in vivo, using guinea pig as a model  for  investigating  the behaviour of  the membrane on  the healing of the  full wound  thickness. 

 Recently, in  a  collaborative  research work  between IPPI  and  SBMU,  by  permission  of  the  National  Ethical  Committee,  several treatment tests were assessed using IPPISkin with or without cultured cell, on the voluntary patients who suffered from either burn injuries, or diseases such as Leishmaniasis or other accidents. IPPISkin clinical performance has shown to alleviate painful autografting and prolonged treatment regimens and has a high capability  for wound healing management and could be considered as suitable candidate for dermal burn healing or cutaneous wounds.